Self-assembling insect ferritin nanoparticles for display of co-assembled trimeric antigens

US10961283B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Peter Kwong · Washington, US
• Ivelin Georgiev · Nashville, US
• Michael Gordon Joyce · Washington, US
• Masaru Kanekiyo · Bethesda, US
• Aliaksandr Druz · Germantown, US
• Ulrich Baxa · Frederick, US
• Joseph Van Galen · North Wales, US
• Cheng Cheng · Bethesda, US
• John Mascola · Rockville, US
• Yaroslav Tsybovsky · Jefferson, US
• Yongping Yang · Potomac, US
• Barney Graham · Rockville, US
• Syed Mohammad Moin · Laurel, US
• Jeffrey Boyington · Clarksburg, US

Key dates

• Filing date: Jun 27, 2017
• Grant date: Mar 30, 2021
• Expiry date: Jun 27, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2770/20034
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided.