Tetrahydro-pyrido[3,4-b]indole estrogen receptor modulators and uses thereof

US10966963B2 · kind B2 · utility

Assignee

• Genentech, Inc. · US

Inventors

• Sharada Labadie · Sunnyvale, US
• Jun Liang · Los Altos Hills, US
• Daniel Fred Ortwine · San Ramon, US
• Xiaojing Wang · Foster City, US
• Jason Zbieg · South San Francisco, US
• Birong Zhang · Union City, US
• Simon Charles Goodacre · Benington, GB
• Nicholas Charles Ray · Witham, GB
• Jun Li · Foster City, US
• Tommy Lai · Kowloon, CN
• Jiangpeng Liao · Shanghai, CN
• Zhiguo Liu · Shanghai, CN
• John S. Wai · Harleysville, US
• Tao Wang · Farmington, US

Key dates

• Filing date: Apr 17, 2018
• Grant date: Apr 6, 2021
• Expiry date: Apr 17, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure:and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.