Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels

US10968210B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Thomas J. Greshock · Collegeville, US
• James Mulhearn · Cheltenham, US
• Anthony J. Roecker · Harleysville, US
• Tianying Jian · Westfield, US
• Gang Zhou · Bound Brook, US
• Liangqin Guo · Edison, US
• Walter Won · Alpine, US
• Ting Zhang · Princeton Junction, US
• Rajan Anand · Wilmington, US
• John E. Stelmach · Westfield, US
• Deping Wang · Furlong, US
• Ronald Kim · Essen, DE
• Mark E. Layton · Harleysville, US
• Christopher S. Burgey · Philadelphia, US
• Philippe G. Nantermet · Lansdale, US

Key dates

• Filing date: Nov 13, 2017
• Grant date: Apr 6, 2021
• Expiry date: Feb 8, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula A, or a salt thereof: Formula (A), wherein: Het, Q and R1A to R4A are defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating cough, itch, acute pain and neuropathic pain disorders using the same.