Macrocyclic indole derivatives

US10981932B2 · kind B2 · utility

Assignees

• BAYER HEALTHCARE LLC · DE
• Bayer Pharma Aktiengesellschaft · DE
• The Broad Institute, Inc. · US

Inventors

• Sarah Anna Liesa Johannes · Düsseldorf, DE
• Philipp Buchgraber · Leverkusen, DE
• Ulrich Klar · Berlin, DE
• Clara Christ · Leverkusen, DE
• Kai Thede · Leverkusen, DE
• Joachim Kuhnke · Leverkusen, DE
• Manfred Moewes · Leverkusen, DE
• Knut Eis · Berlin, DE
• Amaury Ernesto Fernandez-Montalvan · Leverkusen, DE
• Nicolas Werbeck · Berlin, DE
• Ursula Moenning · Mölln, DE
• Philip Lienau · Berlin, DE
• Ulrike Sack · Berlin, DE
• Arne Scholz · Berlin, DE
• Michael H. Serrano-Wu · Cambridge, US
• Chris Lemke · Cambridge, US
• David McKinney · Cambridge, US
• Mark Fitzgerald · Cambridge, US
• Christopher G. Nasveschuk · Stoneham, US
• Kiel Lazarski · Cambridge, US
• Steven James Ferrara · Cambridge, US
• Laura Furst · Cambridge, US
• Guo Ping Wei · Richmond, US
• Patrick R. McCarren · Cambridge, US

Key dates

• Filing date: May 17, 2017
• Grant date: Apr 20, 2021
• Expiry date: May 17, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/22
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical 2019 compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.