Compositions and methods relating to a mutant Clostridium difficile toxin
US10982198B2 · kind B2 · utility
3Cited by
57References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 19, 2018 |
| Grant date | Apr 20, 2021 |
| Priority date | — |
| Expiry date | Aug 19, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N1/20
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. The mutant toxin may include a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to methods and compositions for use in culturing Clostridium difficile and in producing C. difficile toxins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.