Inventor · Garnerville, NY, US

Mark Edward Ruppen

61Patents
12h-index
94Co-inventors
87Inventor score

Filing activity: Jan 26, 1990 → Mar 29, 2023

Most-cited inventions

PatentTitleAreaCited byStatus
US8153768B2 Calicheamicin derivative-carrier conjugates Chemistry; Metallurgy 80 Active
US8986710B2 Neisseria meningitidis compositions and methods thereof Human Necessities 26 Active
US8481692B2 Compositions relating to a mutant Clostridium difficile toxin and methods thereof Chemistry; Metallurgy 22 Active
US9561269B2 Neisseria meningitidis compositions and methods thereof Human Necessities 18 Active
US9724402B2 Neisseria meningitidis composition and methods thereof Human Necessities 18 Active
US9757443B2 Non-lipidated variants of Neisseria meningitidis ORF2086 antigens Emerging Cross-Sectional Technologies 16 Active
US9802987B2 Immunogenic fusion polypeptides Chemistry; Metallurgy 16 Active
US7396660B2 Cloning genes from Streptomyces cyaneogriseus subsp. Noncyanogenus for biosynthesis of antibiotics and methods of use Chemistry; Metallurgy 16 Expired
US7445916B2 Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies Chemistry; Metallurgy 14 Expired
US8652480B2 Shortened purification process for the production of capsular Streptococcus pneumoniae polysaccharides Human Necessities 14 Active
US10226525B2 Group B Streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof Emerging Cross-Sectional Technologies 13 Active
US7268144B2 Regiospecific synthesis of rapamycin 42-ester derivatives Chemistry; Metallurgy 12 Expired
US10512681B2 Non-lipidated variants of Neisseria meningitidis ORF2086 antigens Emerging Cross-Sectional Technologies 11 Active
US8900597B2 Compositions relating to a mutant Clostridium difficile toxin and methods thereof Chemistry; Metallurgy 10 Active
US10196429B2 Neisseria meningitidis composition and methods thereof Human Necessities 10 Active
US10550159B2 Neisseria meningitidis composition and methods thereof Human Necessities 10 Active
US8568735B2 Immunogenic compositions of Staphylococcus aureus antigens Chemistry; Metallurgy 10 Active
US9745354B2 Compositions relating to a mutant Clostridium difficile toxin and methods thereof Chemistry; Metallurgy 9 Active
US9950058B2 RSV F protein mutants Chemistry; Metallurgy 8 Active
US7538119B2 41-Methoxy isotope labeled rapamycin 42-ester Chemistry; Metallurgy 7 Active
US8999697B2 Shortened purification process for the production of capsular Streptococcus pneumoniae polysaccharides Human Necessities 7 Active
USRE46518E1 Compositions relating to a mutant Clostridium difficile toxin and methods thereof General 7 Active
US8747857B2 Calicheamicin derivative-carrier conjugates Chemistry; Metallurgy 7 Expired
US9187536B1 Compositions relating to a mutant Clostridium difficile toxin and methods thereof Chemistry; Metallurgy 7 Active
US9675681B2 Shortened purification process for the production of capsular Streptococcus pneumoniae polysaccharides Human Necessities 7 Active

Source: USPTO / EPO open patent data. Inventor disambiguation is heuristic; counts are objective bibliographic measures.