Coordinated-control coenzyme Q10 fermentation production process based on online oxygen consumption rate and electrical conductivity
US10982242B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 21, 2016 |
| Grant date | Apr 20, 2021 |
| Priority date | — |
| Expiry date | May 21, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/01
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to an optimized fermentation process of coenzyme Q10, particularly to a fermentation process of coenzyme Q10 via flow feeding based on cooperative control of changes of online oxygen consumption rate and conductivity. During the fermentation process of coenzyme Q10 production strains, the oxygen consumption rate is controlled between 30-150 mmol/L·h and the conductivity is maintained between 3.0-30.0 ms/cm via flow feeding, so as to facilitate strain growth and the start of coenzyme Q10 synthesis and accumulation. The present invention can substantially increase output of coenzyme Q10 and greatly reduce the production cost with simple process control and strong operability, thus being applicable to large-scale industrial production.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.