Patent · US Active

Method for the production of a glycosylated immunoglobulin

US11021728B2 · kind B2 · utility

3Cited by

109References

16Claims

0Family size

Assignees

Hoffmann-La Roche Inc. · US
CHUGAI SEIYAKU KABUSHIKI KAISHA · JP

Inventors

Reinhard Franze · Penzberg, DE
Chikashi Hirashima · Tokyo, JP
Thomas Hamilton Link · Pasadena, US
Yoshinori Takagi · Tokyo, JP
Shinya Takuma · Tokyo, JP
Yuriko Tsuda · Tokyo, JP

Key dates

Filing date	Feb 13, 2020
Grant date	Jun 1, 2021
Priority date	—
Expiry date	Feb 13, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/76
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Herein is reported a method for the production of an immunoglobulin comprising the following steps: a) providing a eukaryotic cell comprising a nucleic acid encoding the immunoglobulin, b) cultivating the eukaryotic cell in a cultivation medium wherein the amount of glucose available in the cultivation medium per time unit is kept constant and limited to less than 80% of the amount that could maximally be utilized by the cells in the cultivation medium per time unit, and c) recovering the immunoglobulin from the culture.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.