Glucose responsive insulin comprising a tri-valent sugar cluster for treatment of diabetes
US11041009B2 · kind B2 · utility
1Cited by
10References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 19, 2018 |
| Grant date | Jun 22, 2021 |
| Priority date | — |
| Expiry date | Mar 19, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An insulin conjugate comprising or consisting of a tri-valent sugar cluster is described. In particular aspects, the insulin conjugate displays a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.