Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
US11066705B2 · kind B2 · utility
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Key dates
| Filing date | Nov 24, 2015 |
| Grant date | Jul 20, 2021 |
| Priority date | — |
| Expiry date | Oct 21, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/156
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods of monitoring and measuring dynamic adaptive immune cell responses are provided. High-throughput sequencing of T cell receptor and immunoglobulin loci is used to characterize the breadth of an effector cell response to a stimulus, such as a vaccine or infection. Unique responding effector cell clones and abundance thereof can be determined. Additionally, methods for determining the contribution of responding effector cells to the immunological memory compartment are provided.
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