Formulation for parenteral administration

US11077050B2 · kind B2 · utility

Assignees

• Merck Sharp & Dohme LLC · US
• MERCK SHARP & DOHME B.V. · NL

Inventors

• Sachin Mittal · Bound Brook Junction, US
• Irina Kazakevich · Rockaway, US
• Himanshu Bhattacharjee · Memphis, US
• Peter Bakker · Zeist, NL
• Luke Ryan Schenck · Yardley, US
• David J. Goldfarb · Highland Park, US
• Amitava Mitra · Lincoln, US
• Donna Carroll · Garwood, US
• Nazia Khawaja · Morristown, US

Key dates

• Filing date: Mar 19, 2018
• Grant date: Aug 3, 2021
• Expiry date: Jul 28, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The instant invention provides pharmaceutical formulations for a long acting injectable drug product comprising a suspension of doravirine for parenteral administration via intramuscular or subcutaneous routes. The drug product can be used for the treatment or prophylaxis of infection by HIV or for the treatment, prophylaxis, or delay in the onset of AIDS (acquired immunodeficiency syndrome) or ARC (AIDS related complex).