Chimeric antigen receptor (CAR) that targets chemokine receptor CCR4 and its use

US11077178B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• United States Government as represented by the Department of Veterans Affairs · US

Inventors

• Liyanage Parakrama Perera · Bethesda, US
• Thomas Waldmann · Silver Spring, US
• Kevin Charles Conlon · Bethesda, US
• Pin-Yu Perera · Washington, US

Key dates

• Filing date: Sep 20, 2017
• Grant date: Aug 3, 2021
• Expiry date: Sep 20, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/33
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A chimeric antigen receptor is disclosed that includes: (a) an scFv comprising a light chain variable domain (VL) and a heavy chain variable domain (VH), wherein the scFv specifically binds to CCR4; (b) a hinge and transmembrane domain from CD8; (c) an intracellular 4-1BB signaling domain; and (d) an intracellular CD3 zeta signaling domain, wherein (a)-(d) are in N to C terminal order. Uses of the chimeric antigen receptor, such as for treating a malignancy, are also disclosed.