Enhancing immunogenicity of Streptococcus pneumoniae polysaccharide-protein conjugates
US11090374B2 · kind B2 · utility
3Cited by
4References
14Claims
0Family size
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Key dates
| Filing date | Feb 20, 2018 |
| Grant date | Aug 17, 2021 |
| Priority date | — |
| Expiry date | Feb 20, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/6037
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from Streptococcus pneumoniae bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.