Compounds and methods useful for treating or preventing hematological cancers

US11096934B2 · kind B2 · utility

Assignees

• The Broad Institute, Inc. · US
• The General Hospital Corporation · US
• President and Fellows of Harvard College · US
• Bayer Pharma Aktiengesellschaft · DE

Inventors

• David B. Sykes · Cambridge, US
• David T. Scadden · Leeuwerikstraat, US
• Timothy A. Lewis · Marlborough, US
• Andreas Janzer · Berlin, DE
• Hanna Meyer · Berlin, DE
• Detlef STÖCKIGT · Potsdam, DE

Key dates

• Filing date: Aug 29, 2016
• Grant date: Aug 24, 2021
• Expiry date: Oct 17, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention includes methods of treating patients with acute myeloid leukemia across a range of genetic subtypes with DHODH inhibitors, such as 6-fluoro-2-(2′-fluoro-[1,1′-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid).