Compositions and methods for treating cardiac dysfunction
US11111296B2 · kind B2 · utility
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5References
7Claims
0Family size
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Key dates
| Filing date | Dec 13, 2016 |
| Grant date | Sep 7, 2021 |
| Priority date | — |
| Expiry date | Dec 13, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/34
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides compositions and methods for treating cardiac dysfunction, particularly cachexia-associated or RAGE-associated cardiac dysfunction, using an anti-RAGE agent. The invention also provides compositions and methods for identifying therapeutic agents useful for disrupting (slowing, reducing, reversing, or preventing). The methods comprise designing or identifying agents that bind to functional sites identified on the RAGE polypeptide, wherein binding of agents to the functional site(s) inhibit RAGE-mediated cachetogenic signaling.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.