Kappa opioid receptor antagonists and products and methods related thereto

US11124504B2 · kind B2 · utility

Assignees

• THE SCRIPPS RESEARCH INSTITUTE · US
• BLACKTHORN THERAPEUTICS, INC. · US

Inventors

• Edward Roberts
• Miguel A. Guerrero · San Diego, US
• Mariangela Urbano · Del Mar, US
• Hugh Rosen · Village of La Jolla, US
• Robert M. Jones · San Diego, US
• Candace Mae Laxamana · South San Francisco, US
• Xianrui Zhao · South San Francisco, US
• Eric D. Turtle · Belmont, US

Key dates

• Filing date: Apr 10, 2020
• Grant date: Sep 21, 2021
• Expiry date: Apr 10, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds are provided that antagonize the kappa-opioid receptor (KOR) and products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof: wherein X, Y, R1, R2, R4, R5 R6, R7, R8 and R11 are as defined herein.