Patent · US Active

Synthesis of labeled imidazo[1,2-A]pyrimidines

US11136330B2 · kind B2 · utility

0Cited by

4References

38Claims

0Family size

Assignee

Genentech, Inc. · US

Inventors

Kyle Bradley Pascual Clagg · San Francisco, US
Nicholas Andrew White · San Francisco, US
Haiming Zhang · Pennington, US
Francis Gosselin · South San Francisco, US
William Nack · Glenview, US
Paul O'Shea · Westmount, CA

Key dates

Filing date	May 7, 2020
Grant date	Oct 5, 2021
Priority date	—
Expiry date	May 7, 2040

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A method of synthesizing comprising a step of making an imidazo-pyrimidine compound by coupling a first compound of formula (II) with a second compound of formula (III) Followed by a deprotection and tosylation step. The methods are able to produce an isotopically substituted molecule having upwards of 95% purity relative to non-isotopically substituted molecules.The invention further comprises compounds of formula:

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.