Recombinant HIV-1 envelope proteins and their use

US11136356B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Peter Kwong · Washington, US
• John Mascola · Rockville, US
• Gwo-Yu Chuang · Rockville, US
• Hui Geng · Rockville, US
• Yongping Yang · Potomac, US
• Cheng Cheng · Bethesda, US
• Jeffrey Boyington · Clarksburg, US
• Yen-Ting Lai · Bethesda, US

Key dates

• Filing date: Oct 16, 2018
• Grant date: Oct 5, 2021
• Expiry date: Oct 16, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16134
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Immunogens comprising a recombinant HIV-1 Env ectodomain trimer stabilized in a prefusion closed conformation and methods of their use and production are disclosed. In several embodiments, the immunogen can be used to elicit an immune response to HIV-1 in a subject.