Optical device for non-invasive continuous monitoring of blood glucose level and HbA1c concentration
US11141087B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Apr 15, 2020 |
| Grant date | Oct 12, 2021 |
| Priority date | — |
| Expiry date | Apr 15, 2040 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B2562/0238
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A sensor device which is adapted for detecting target molecules in-vitro and in-vivo, comprises a MIR source for exciting the target species and a probe beam with split frequency to measure the effect of excitation. The latter uses a heterodyne interferometer operating at a beat frequency ˜ KHz. to MHz. The photo-thermal excitation of target species leads to refractive index change. The RI change produces probe beam displacement and is measured using a 1) grating heterodyne interferometer, 2) grating deflection amplifier and 3) evanescent field heterodyne interferometer. The measured RI change can be related to specie concentration change in target volume. Furthermore, a sensing method for detecting HbA1c concentration and its change with thermal excitation is described in terms of phase shift of the OCT spectrum obtained with spectral domain optical coherence tomography (SD-OCT).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.