Compounds, compositions and methods for cancer treatment

US11142522B2 · kind B2 · utility

Assignees

• The Broad Institute, Inc. · US
• DANA-FARBER CANCER INSTITUTE, INC. · US
• BAYER HEALTHCARE LLC · DE
• Bayer Pharma Aktiengesellschaft · DE

Inventors

• Timothy A. Lewis · Marlborough, US
• Xiaoyun Wu · Chesterfield, US
• Heidi Greulich · Cambridge, US
• Matthew Meyerson · Concord, US
• Manuel Ellermann · Berlin, DE
• Philip Lienau · Berlin, DE
• Knut Eis · Berlin, DE
• Antje Margret Wengner · Berlin, DE
• Charlotte Christine Kopitz · Falkensee, DE
• Martin Lange · Berlin, DE

Key dates

• Filing date: Feb 1, 2018
• Grant date: Oct 12, 2021
• Expiry date: Feb 1, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D237/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention features improved compounds, especially the compound having the structure (1). Compositions and methods of identifying patients having cancer using biomarkers (e.g., PDE3A, PDE3B, SLFN12 and/or CREB3L1) that correlate with drug sensitivity and consequently treating a stratified patient population with an agent of the invention.