Tumor infiltrating lymphocytes and methods of therapy

US11154574B2 · kind B2 · utility

Assignees

• Regents of the University of Minnesota · US
• INTIMA BIOSCIENCE, INC. · US
• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Branden Moriarity · Shoreview, US
• Beau Webber · Coon Rapids, US
• Modassir Choudhry · New York, US
• Steven A. Rosenberg · Potomac, US
• Douglas C. Palmer · North Bethesda, US
• Nicholas P. Restifo · Chevy Chase Section Five, US

Key dates

• Filing date: May 28, 2020
• Grant date: Oct 26, 2021
• Expiry date: May 28, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2510/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.