Therapeutic compounds and uses thereof

US11168070B2 · kind B2 · utility

Assignees

• Genentech, Inc. · US
• Constellation Pharmaceuticals, Inc. · US

Inventors

• Patrick Cyr · South San Francisco, US
• Sarah Bronner · South San Francisco, US
• F. Anthony Romero · South San Francisco, US
• Steven R. Magnuson · South San Francisco, US
• Vickie Hsiao-Wei Tsui · Burlingame, US
• John S. Wai · Harleysville, US
• Kwong Wah Lai · Shanghai, CN
• Fei Wang · Beijing, CN

Key dates

• Filing date: May 28, 2020
• Grant date: Nov 9, 2021
• Expiry date: May 28, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula (I) and formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R5-R6 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II), or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.