Substituted carbapenems for the treatment of bacterial infections

US11180504B2 · kind B2 · utility

Assignees

• ORCHID PHARMA LTD. · IN
• Merck Sharp & Dohme LLC · US

Inventors

• Gopalan Balasubramanian · Chennai, IN
• Maneesh Paul-Satyaseela · Chennai, IN
• Chidambaram Venkateswaran Srinivasan · Chennai, IN
• Sridhar Ramanathan Iyer · Chennai, IN
• Hariharan Periasamy · Chennai, IN
• Venkatesan Parameswaran · Chennai, IN
• Bharani Thirunavukkarasu · Chennai, IN
• Prabhakar Rao Gunturu · Chennai, IN
• Manjula Devi Deshkumar · Chennai, IN
• Venkateshwarlu Jakkala · Chennai, IN
• Michael Miller · Scotch Plains, US
• Ravi Nargund · East Brunswick Township, US
• Sheo B. Singh · Tempe, US
• Shuzhi Dong · Plainsboro, US
• Hongwu Wang · Westfield, US
• Katherine Young · Metuchen, US

Key dates

• Filing date: Mar 15, 2017
• Grant date: Nov 23, 2021
• Expiry date: Feb 12, 2038

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to carbapenem compounds of the following formula: wherein A, Z, X, R1, and R4 are as described herein, as well as stereoisomers, pharmaceutically acceptable salts or N-oxides thereof, which may be useful for the treatment of bacterial infections, particularly drug-resistant bacterial infections, as well as the processes for the preparation of compounds, the pharmaceutical compositions of these compounds and their use in the treatment of bacterial infection.