Process for synthesis and purification of (2R,6R)-hydroxynorketamine

US11186539B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Craig J. Thomas · Gaithersburg, US
• Patrick Morris · Laurel, US
• Richard Andrew Castledine · Rothbury, GB
• Samuel Lawrence Bourne · Rothbury, GB

Key dates

• Filing date: Jun 4, 2019
• Grant date: Nov 30, 2021
• Expiry date: Jun 4, 2039

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of (2R,6R)-hydroxynorketamine is provided. The process requires no chromatography purification and affords the (2R,6R)-hydroxynorketamine in eight steps with a 26% overall yield and greater than 97% purity.