Patent · US Active

Non-human primate induced pluripotent stem cell derived hepatocytes and uses thereof

US11208629B2 · kind B2 · utility

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11Claims

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Assignee

Hoffmann-La Roche Inc. · US

Inventors

Eva Christina Thoma · Basel, CH
Martin Graf · Richmond, US
Vanessa Hunt · Basel, CH

Key dates

Filing date	Jan 25, 2019
Grant date	Dec 28, 2021
Priority date	—
Expiry date	Jan 25, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2533/90
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

This application relates to non-human primate (NHP) induced pluripotent stem cell (IPSC)-derived hepatocytes, for example, Cynomolgus monkey (Macaca fascicularis) induced pluripotent stem cell-derived hepatocytes, and methods of producing the same. Moreover, this application relates to methods of using NHP IPSC-derived hepatocytes for drug screening, drug safety assessment and in models of infection.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.