Phenylpyrazolylacetamide compounds and derivatives as CDK8/CDK19 inhibitors

US11213520B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Harald Engelhardt · Ebreichsdorf, AT
• Heribert Arnhof · Wien, AT
• Sebastian CAROTTA · Wien, AT
• Marco Hofmann · Wien, AT
• Marc Kerenyi · Wien, AT
• Dirk Scharn · Wien, AT

Key dates

• Filing date: May 19, 2017
• Grant date: Jan 4, 2022
• Expiry date: May 19, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention encompasses compounds of formula (I) wherein the groups R2 to R5, A, X and q have the meanings given in the claims and specification, their use as inhibitors of CDK8/19, pharmaceutical compositions which contain compounds of this kind and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases.