Means for diagnosing, predicting or monitoring Pneumocystis pneumonia

US11236390B2 · kind B2 · utility

Assignees

• INSTITUT PASTEUR · FR
• ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS (APHP) · FR
• UNIVERSITÉ PARIS DIDEROT—PARIS 7 · FR

Inventors

• Alexandre Alanio · Bourg-la-Reine, FR
• Stéphane Bretagne · Verrières-le-Buisson, FR
• Françoise Dromer · Paris, FR
• Aude STURNY-LECLERE · Cluses, FR
• Benjamin HOMMEL · Paris, FR
• Marion BENAZRA · Brétigny-sur-Orge, FR

Key dates

• Filing date: Apr 15, 2016
• Grant date: Feb 1, 2022
• Expiry date: Aug 16, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/16
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The application relates to means for diagnosing, predicting or monitoring Pneumocystis pneumonia (PCP). The means of the application are also suitable for determining or predicting the efficacy of a drug or treatment against PCP in a human patient. The means of involve the detection and/or quantification, more particularly the quantification, of the RNA transcripts of two different P. jirovecii mitochondrial genes. The first of said two P. jirovecii mitochondrial genes is the P. jirovecii gene, the sequence of which codes for the Cytb protein or the P. jirovecii mitochondrial Small Sub-Unit (mtSSU) gene. The second of said two P. jirovecii mitochondrial genes is a P. jirovecii gene, the sequence of which transcribes into a P. jirovecii ribosomal RNA, e.g., be the mitochondrial P. jirovecii Large Sub-Unit (mtLSU) gene.