(4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof
US11242344B2 · kind B2 · utility
1Cited by
6References
29Claims
0Family size
Assignee
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Key dates
| Filing date | Apr 24, 2020 |
| Grant date | Feb 8, 2022 |
| Priority date | — |
| Expiry date | Apr 24, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure relates to bifunctional compounds, which can be used as modulators of targeted ubiquitination. In particular, the present disclosure is directed to compounds which contain on one end a VHL ligand moiety, which binds to the VHL E3 ubiquitin ligase, and on the other end a moiety that binds a target protein such that degradation of the target protein/polypeptide is effectuated. Also disclosed are VHL ligands.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.