Methods of treatment using ultrasmall nanoparticles to induce cell death of nutrient-deprived cancer cells via ferroptosis

US11246946B2 · kind B2 · utility

Assignees

• Memorial Sloan Kettering Cancer Center · US
• Cornell University · IT

Inventors

• Michelle S. Bradbury · Andover, US
• Ulrich Wiesner · Ithaca, US
• Michael Overholtzer · Glen Ridge, US
• Howard Scher · Tenafly, US
• Kai Ma · Ithaca, US

Key dates

• Filing date: Jun 16, 2020
• Grant date: Feb 15, 2022
• Expiry date: Jun 16, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein is a method of induced cell death via ferroptosis by nanoparticle ingestion. Moreover, the present disclosure describes the administration of high concentrations of ultrasmall nanoparticles at multiple times over the course of treatment in combination with a nutrient-depleted environment, thereby modulating cellular metabolic pathways to induce cell death by the mechanism ferroptosis. Ferroptosis involves iron, reactive oxygen species, and a synchronous mode of cell death execution.