Somatostatin prodrugs

US11261215B2 · kind B2 · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Amnon Hoffman · Jerusalem, IL
• Chaim Gilon · Jerusalem, IL
• Adi Klinger · Rishon LeZion, IL
• Johnny NAOUM · Haifa, IL

Key dates

• Filing date: Sep 17, 2018
• Grant date: Mar 1, 2022
• Expiry date: Sep 17, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/31
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides prodrugs of somatostatin peptide and peptide analogs that are tissue permeable and oral bioavailable and enable activity of the somatostatin analog at the circulation or target tissue after cleavage of charge-masking lipophilic moieties. Pharmaceutical compositions comprising these prodrugs and their use in therapy and diagnosis are also provided.