Recombinant chimeric bovine/human parainfluenza virus 3 expressing RSV G and its use

US11273214B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Peter L. Collins · Kensington, US
• Ursula Buchholz · Silver Spring, US
• Bo Liang · Maoming, CN
• Shirin Munir · Bethesda, US

Key dates

• Filing date: May 29, 2018
• Grant date: Mar 15, 2022
• Expiry date: Jul 16, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/18643
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Recombinant chimeric bovine/human parainfluenza virus 3 (rB/HPIV3) vectors expressing Respiratory Syncytial Virus (RSV) G protein or a recombinant RSV G protein, as well as methods of their use and manufacture, are provided. The rB/HPIV3 vector comprises a genome comprising a heterologous gene encoding the RSV G protein or the recombinant RSV G protein. Nucleic acid molecules comprising the sequence of the genome or antigenome of the disclosed rB/HPIV3 vectors are also provided. The disclosed rB/HPIV3 vectors can be used, for example, to induce an immune response to RSV and HPIV3 in a subject.