Tubulysin analogues as anticancer agents and payloads for antibody-drug conjugates and methods of treatment therewith
US11274124B2 · kind B2 · utility
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19Claims
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Assignee
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Key dates
| Filing date | Nov 28, 2018 |
| Grant date | Mar 15, 2022 |
| Priority date | — |
| Expiry date | Nov 28, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.