Cyclic peptide antibiotics

US11279735B2 · kind B2 · utility

Assignee

• Genentech, Inc. · US

Inventors

• Emily Hanan · Redwood City, US
• Georgette Castanedo · Redwood City, US
• Marie-Gabrielle Braun · South San Francisco, US
• Keira Garland · South San Francisco, US
• Peter Andrew Smith · San Francisco, US
• Richard Pastor · South San Francisco, US
• Paul Gibbons · San Francisco, US
• Yunxing Cheng · Beijing, CN
• Guosheng Wu · Beijing, CN
• Yuhong FU · Beijing, CN
• Po-Wai Yuen · Ann Arbor, US

Key dates

• Filing date: Mar 12, 2020
• Grant date: Mar 22, 2022
• Expiry date: Mar 12, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.