Therapeutic and diagnostic methods for cancer

US11279767B2 · kind B2 · utility

Assignees

• Genentech, Inc. · US
• Foundation Medicine, Inc. · US

Inventors

• Richard BOURGON · South San Francisco, US
• David Fabrizio · Hamilton, US
• Gregg FINE · South San Francisco, US
• Garrett Michael Frampton · Somerville, US
• Priti HEGDE · San Mateo, US
• Sanjeev Mariathasan · Millbrae, US
• Philip James Stephens · Lexington, US
• James Xin Sun · Cambridge, US
• Roman Yelensky · Newton, US

Key dates

• Filing date: Aug 28, 2018
• Grant date: Mar 22, 2022
• Expiry date: May 29, 2039

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A90/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides therapeutic and diagnostic methods and compositions for cancer, for example, bladder cancer. The invention provides methods of treating bladder cancer, methods of determining whether a patient suffering from bladder cancer is likely to respond to treatment comprising a PD-L1 axis binding antagonist, methods of predicting responsiveness of a patient suffering from bladder cancer to treatment comprising a PD-L1 axis binding antagonist, and methods of selecting a therapy for a patient suffering from bladder cancer, based on somatic mutation levels of genes of the invention (e.g., somatic mutation levels in a tumor sample obtained from the patient).