Anti-PD-1 nano-antibody and application thereof
US11292841B2 · kind B2 · utility
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11Claims
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Key dates
| Filing date | Sep 11, 2017 |
| Grant date | Apr 5, 2022 |
| Priority date | — |
| Expiry date | Feb 19, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/76
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An anti-PD-1 nano-antibody capable of blocking a binding interaction between PD-1 and a ligand thereof, PD-L1. Disclosed are the nano-antibody, a nucleotide sequence encoding the nano-antibody, a corresponding expression vector, a host cell expressing the nano-antibody, and a method of producing the nano-antibody. Also disclosed is a humanized PD-1 nano-antibody sequence. The humanized nano-antibody can block the binding interaction between PD-1 and the ligand thereof, PD-L1 while still retaining a high affinity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.