Dopamine D3 receptor selective antagonists/partial agonists; method of making; and use thereof

US11299476B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Amy Hauck Newman · Phoenix, US
• Vivek Kumar · Delhi, IN
• Anver Basha Shaik · Hyderabad, IN

Key dates

• Filing date: Mar 8, 2017
• Grant date: Apr 12, 2022
• Expiry date: Oct 3, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed herein novel dopamine D3 receptor selective antagonists/partial agonists compounds with high affinity and metabolic stability useful for the treatment of psychiatric and neurological disorders and as research and diagnostic tools. Also disclosed are methods of making the compounds.