Methods of producing two chain proteins in bacteria
US11299539B2 · kind B2 · utility
2Cited by
46References
64Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 21, 2018 |
| Grant date | Apr 12, 2022 |
| Priority date | — |
| Expiry date | Jan 25, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/31
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided herein are methods of producing a polypeptide containing two chains, such as an antibody including a light chain and a heavy chain. In particular, methods are provided for producing heterologous secretory proteins in bacteria through utilization of optimized expression vectors and culture processes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.