Patent · US Active

Method for the selection of a long-term producing cell using histone acylation as markers

US11332797B2 · kind B2 · utility

0Cited by

0References

15Claims

0Family size

Assignee

Hoffmann-La Roche Inc. · US

Inventors

Ulrich Goepfert · Penzberg, DE
Peter Becker · Gaggenau, DE
Benjamin Moritz · Munich, DE

Key dates

Filing date	May 13, 2015
Grant date	May 17, 2022
Priority date	—
Expiry date	May 13, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q2600/154
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Herein is reported a method for determining methylation of a promoter nucleic acid operably linked to a nucleic acid encoding a polypeptide and thereby determining the long-term productivity of a cell. Also an aspect is a method for selecting a cell for producing a polypeptide by determining the methylation of the promoter nucleic acid operably linked to the structural gene encoding the polypeptide.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.