Stabilized group 2 influenza hemagglutinin stem region trimers and uses thereof

US11338033B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Jeffrey Boyington · Clarksburg, US
• Barney Graham · Rockville, US
• John Mascola · Rockville, US
• Hadi M. Yassine · Doha, QA
• Kizzmekia Corbett · Wheaton, US
• Syed Mohammad Moin · Laurel, US
• Lingshu Wang · North Potomac, US
• Masaru Kanekiyo · Bethesda, US

Key dates

• Filing date: Sep 1, 2017
• Grant date: May 24, 2022
• Expiry date: Sep 1, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/16134
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Vaccines that elicit broadly protective anti-influenza antibodies. The vaccines comprise nanoparticles that display HA trimers from Group 2 influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to stabilized stem regions of Group 2 influenza virus HA proteins. The fusion proteins self-assemble to form the HA-displaying nanoparticles. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.