Methods for preparing stabilized amorphous drug formulations using acoustic fusion
US11344496B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 20, 2018 |
| Grant date | May 31, 2022 |
| Priority date | — |
| Expiry date | Aug 20, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/38
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods for producing a stable amorphous dispersion of a pharmaceutically active substance having poor water solubility by applying low frequency acoustic energy to a mixture comprising the active substance and at least one polymer and heating the mixture until a stable amorphous dispersion is formed. The methods of the invention are an effective means of converting a crystalline API to a substantially amorphous and stable form, i.e., wherein the crystallinity is less than about 5%. The methods of the invention result in more complete amorphization, increased solubility, drug loading and stability as compared typical amorphization or literature methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.