Methods for the preparation of ribosides
US11344565B2 · kind B2 · utility
Assignee
Inventors
- Steven D. Axt
- Pavel R. Badalov
- Katrien Brak
- Silvio Campagna
- Andrei Chtchemelinine
- Edward Doerffler
- Morin Mae Frick
- Detian Gao
- Lars V. Heumann
- Brittanie Hoang
- Willard Lew
- Robert R. Milburn
- Sean T. Neville
- Bruce Ross
- Erik J. Rueden
- Robert Scott
- Dustin Siegel
- Andrew C. Stevens
- Clarissa Tadeus
- Tiago Vieira
- Andrew W. Waltman
- Xianghong Wang
- Mark Charles Whitcomb
- Lydia Wolfe
- Chia-Yun Yu
Key dates
| Filing date | Oct 29, 2015 |
| Grant date | May 31, 2022 |
| Priority date | — |
| Expiry date | Jun 26, 2036 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are methods of preparing compounds and pharmaceutical compositions comprising a compound Formula VIII for treating Filoviridae virus infections. In one aspect, the compound of Formula VIII is formed from a reaction mixture comprising the compound of Formula IX, the compound of Formula X, a coupling agent such as magnesium chloride and a non-nucleophilic base such as diisopropylethylamine. The compound of Formula IX can be formed from a compound of Formula V and a cyanating agent. The compound of Formula V can be synthesized from a reaction mixture comprising a deprotonating agent such as phenylmagnesium chloride; a silylating agent such as chlorotrimethylsilane; a coupling agent such as isopropylmagnesium chloride, an additive such as LaCl3-2LiCl, LaCl3, CeCl3, NdCl3, or YCl3; a compound of Formula VI; and 7-iodopyrrolo[2,1-f][1,2,4]triazin-4-amine. The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.