Methods of preparing inhibitors of influenza viruses replication

US11345700B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Gerald J. Tanoury · Marlborough, US
• William A. Nugent · Wilmington, US
• Vadims Dvornikovs · Lancaster, US
• Peter Jamison Rose · Littleton, US

Key dates

• Filing date: Mar 9, 2020
• Grant date: May 31, 2022
• Expiry date: Mar 9, 2040

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (X): or a pharmaceutically acceptable salt thereof with Compound (Y): in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z): or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound (Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.