Substituted [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors

US11352320B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Shuwen He · Fanwood, US
• Dane Clausen · Rahway, US
• Liangqin Guo · Edison, US
• Yongxin Han · Kirkland, CA
• Xianhai Huang · Hackettstown, US
• Alexander Pasternak · Brookline, US
• Qinglin Pu · Needham, US
• Dong Xiao · Hackettstown, US
• Li Xiao · Cranbury, US
• Feng Ye · Scotch Plains, US
• Hongjun Zhang · Waterloo, CA

Key dates

• Filing date: May 28, 2019
• Grant date: Jun 7, 2022
• Expiry date: May 28, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/38
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.