Biased potent opioid-like agonists as improved medications to treat chronic and acute pain and methods of using the same

US11352365B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Kenner C. Rice · Bethesda, US
• Arthur E. Jacobson · Rockville, US
• Fuying Li · Rockville, US
• Eugene S. Gutman · Holland, US
• Eric W. Bow · Washington, US

Key dates

• Filing date: Mar 18, 2019
• Grant date: Jun 7, 2022
• Expiry date: Mar 18, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P29/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is directed to a compound having Formula (I) and its enantiomer: wherein the definitions of n, R, X, Y and Y3, and Z are provided in the disclosure. The invention is also directed to pharmaceutical compositions of the disclosed compounds, as well as their use as opioid-like agonists in the treatment of pain.