Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors
US11370776B2 · kind B2 · utility
5Cited by
12References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 4, 2018 |
| Grant date | Jun 28, 2022 |
| Priority date | — |
| Expiry date | Jul 4, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/502
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to compounds of formula (I): wherein Q is O or S, R1 is a 6-membered heteroaryl group containing at least one nitrogen atom in the 6-membered ring structure, wherein R1 may optionally be substituted, and R2 is a cyclic group substituted at the α-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.