Methods of conjugating an agent to a thiol moiety in a protein that contains at least one sulfide bond
US11370838B2 · kind B2 · utility
0Cited by
17References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 24, 2017 |
| Grant date | Jun 28, 2022 |
| Priority date | — |
| Expiry date | Jul 7, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/2803
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides improved methods of conjugating an agent to a thiol moiety in a protein that contains at least one disulfide bond and at least one trisulfide bond. Exemplary embodiments include the production of antibody drug conjugates substantially free of impurities created in the presence of reactive sulfide moieties in the production processes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.