Patent · US Active

Identification of calibration deviations of pH-measuring devices

US11371006B2 · kind B2 · utility

0Cited by

3References

17Claims

0Family size

Assignee

Hoffmann-La Roche Inc. · US

Inventors

Detlef Eisenkraetzer · Iffeldorf, DE
Christian Klinger · Penzberg, DE
Katrin Greppmair · Penzberg, DE

Key dates

Filing date	Oct 28, 2016
Grant date	Jun 28, 2022
Priority date	—
Expiry date	Dec 12, 2036

Classification

Technology area (CPC G)Physics
CPC primaryG05D21/02
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The invention relates to a comparison unit (130) configured for determining if a first pH measuring device of a first tank (104; 106) is affected by a pH-measuring problem, the comparison unit being configured for: —receiving a first CO2 concentration and a first pH value, the first CO2 concentration being a CO2 concentration of a first gas volume above a medium in a first tank, the first CO2 concentration and the first pH value being measured at a first time when the medium in the first tank is in pH-CO2 equilibrium state with the first gas volume and before said equilibrium state is modified by the metabolism of a cell culture in the first tank, the first pH value being a measured value provided by a first pH measuring device operatively coupled to the first tank (102); —receiving a second CO2 concentration and a second pH value, the second CO2 concentration being a CO2 concentration of a second gas volume above a medium in a second tank, the second CO2 concentration and the second pH value being measured at a second time when the medium in the second tank is in pH-CO2 equilibrium state with the second gas volume and before said equilibrium state is modified by the metabolism of …

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.