Targeting agent antibody conjugates and uses thereof

US11377496B2 · kind B2 · utility

Assignee

• THE SCRIPPS RESEARCH INSTITUTE · US

Inventors

• Chanhyuk Kim · San Diego, US
• Jun Y. AXUP · San Diego, US
• Hwayoung YUN · Daejeon, KR
• Peter G. Schultz · Village of La Jolla, US
• Jennifer Ma · Los Angeles, US
• Jiayin Shen · San Diego, US
• Pengyu Yang · San Diego, US

Key dates

• Filing date: May 22, 2019
• Grant date: Jul 5, 2022
• Expiry date: May 6, 2040

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods, compositions and uses are provided for bispecific antibodies comprising one or more unnatural amino acids. The bispecific antibodies may bind to two or more different receptors, co-receptors, antigens, or cell markers on one or more cells. The bispecific antibodies may be used to treat a disease or condition (e.g., cancer, autoimmune disease, pathogenic infection, inflammatory disease). The bispecific antibodies may be used to modulate (e.g., stimulate or suppress) an immune response.