Anti-mesothelin polypeptides and proteins

US11390683B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Ira H. Pastan · Potomac, US
• Masanori Onda · Germantown, US
• Tapan Bera · Germantown, US
• Mitchell Ho · Urbana, US

Key dates

• Filing date: May 17, 2018
• Grant date: Jul 19, 2022
• Expiry date: Oct 13, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2800/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Polypeptides and proteins that specifically bind to and immunologically recognize human mesothelin582-598 (IP-NGYLVLDLSMQEALS) (SEQ ID NO: 1) are disclosed. Anti-mesothelin binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and conjugates relating to the polypeptides and proteins are disclosed. Methods of reducing mesothelin shed from cell membranes, methods of reducing the activity of TNFα converting enzyme, methods of detecting the presence of cancer, and methods of treating or preventing cancer are also disclosed.