Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)

US11390921B2 · kind B2 · utility

Assignee

• Adaptive Biotechnologies Corporation · US

Inventors

• Marcos MILLA · Carlsbad, US
• Mark Klinger · Seattle, US
• Peter J. R. Ebert · Seattle, US
• Timothy Lee Hayes · Seattle, US
• Edward J. Osborne · Seattle, US
• Joyce K. Hu · Seattle, US

Key dates

• Filing date: Jun 13, 2018
• Grant date: Jul 19, 2022
• Expiry date: Jun 28, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is directed to methods for determining antigen-specific T cells generally and to T cell receptors which bind an epitope of the Wilms' tumor antigen-1 (WT1) protein specifically. The disclosure also provides polynucleotides encoding the TCRs, engineered cells exogenously expressing the TCRs, and methods of making and using the TCRs and/or cells expressing the TCRs.